Syrian rebels attacked a checkpoint in a pro-government suburb of Damascus, setting off a suicide vehicle bomb that killed 16 soldiers, according to activists.
It came as the UN-Arab League envoy began a regional push for peace talks.
Meanwhile, the US said children were starving to death in besieged areas of the capital and demanded that the regime allow aid convoys in.
The Syrian Observatory for Human Rights said a suicide bomber from the al Qaeda-linked Al Nusra Front detonated an explosives-packed car at the checkpoint between Jaramana and the rebel-held area of Mleha.
State media blamed the blast on "terrorists", the regime term for rebels.
Heavy fighting followed, with rebel mortar fire hitting Jaramana, said the Britain-based Observatory, which relies on activists and medics on the ground for its information.
One resident said the intensity of fighting was "unprecedented" since the conflict erupted in March 2011.
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